Alpha-linolenic Acid And COPD

mark

2011-12-05 10:55:32 UTC

Post by ironjustice
"ALA (an anti-inflammatory omega-3 fatty acid) was associated with
lower TNFα "
Association between Ω3 and Ω6 fatty acid intakes and serum
inflammatory markers in COPD
The Journal of Nutritional Biochemistry
Jordi de Batllea, b, c, d, Jaume Sauledae, f, g, Eva Balcellsb, e,
Federico P. Gómeze, h, Michelle Méndeza, b, c, Esther Rodriguezi,
Esther Barreirob, d, e, j, Jaume J. Ferrere, i, Isabelle Romieuk,
Joaquim Geab, d, e, j, Josep M. Antóa, b, c, d, Judith Garcia-
Aymericha, b, c, d, , and PAC-COPD Study Group
a Centre for Research in Environmental Epidemiology, (CREAL),
Barcelona, Spain
b Municipal Institute of Medical Research, (IMIM-Hospital del Mar),
Barcelona, Spain
c CIBER Epidemiología y Salud Pública, (CIBERESP), Barcelona, Spain
d Department of Experimental and Health Sciences, Universitat Pompeu
Fabra (UPF), Barcelona, Spain
e CIBER de Enfermedades Respiratorias (CIBERES), Bunyola, Spain
f Servei de Pneumologia, Hospital Universitari Son Dureta, Palma de
Mallorca, Spain
g Fundació Caubet-Cimera, Bunyola, Spain
h Servei de Pneumologia, Hospital Clínic-Institut D'Investigacions
Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
i Servei de Pneumologia, Hospital General Universitari Vall d'Hebron,
Barcelona, Spain
j Pulmonology department, URMAR, Barcelona, Spain
k Centro de investigación en salud poblacional, Instituto Nacional de
Salud Pública (INSP), Cuernavaca, Mexico
Received 14 October 2010; revised 4 April 2011; Accepted 8 April 2011.
Available online 1 September 2011.
Abstract
Dietary intake of polyunsaturated fatty acids, including omega-3 and
omega-6, could modulate chronic obstructive pulmonary disease (COPD)
persistent inflammation.
We aimed to assess the relationship between dietary intake of omega-3
and omega-6 fatty acids and serum inflammatory markers in COPD.
A total of 250 clinically stable COPD patients were included.
Dietary data of the last 2 years were assessed using a validated food
frequency questionnaire (122 items), which provided levels of three
omega-3 fatty acids: docosahexaenoic acid, eicosapentaenoic acid and α-
linolenic acid (ALA); and two omega-6 fatty acids: linoleic acid and
arachidonic acid (AA).
Inflammatory markers [C-reactive protein (CRP), interleukin (IL)-6,
IL-8 and tumor necrosis factor alpha (TNFα)] were measured in serum.
Fatty acids and inflammatory markers were dichotomised according to
their median values, and their association was assessed using
multivariate logistic regression.
Higher intake of ALA (an anti-inflammatory omega-3 fatty acid) was
associated with lower TNFα concentrations [adjusted odds ratio
(OR)=0.46; P=.049].
Higher AA intake (a proinflammatory omega-6 fatty acid) was related to
higher IL-6 (OR=1.96; P=.034) and CRP (OR=1.95; P=.039)
concentrations.
Therefore, this study provides the first evidence of an association
between dietary intake of omega-3 and omega-6 fatty acids and serum
inflammatory markers in COPD patients.
Keywords: Food intake; Inflammation; Public health; Pulmonary disease,
chronic obstructive
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doi:10.1016/j.jnutbio.2011.04.005
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

take those same people in different stages of illness and do something
else which could affect positive change but no our gov would rather
see people suffer.