2012-09-27 03:16:46 UTC
Bråred Christensson J, Andersen KE, Bruze M, Johansen JD, Garcia-Bravo
B, Gimenez Arnau A, Goh CL, Nixon R, White IR
Contact Dermatitis (Aug 2012)
Linalool is a common fragrance terpene that, in pure form, is not
allergenic or is a very weak allergen.
However, linalool autoxidizes on air exposure, and the oxidation
products can cause contact allergy.
In a Swedish study, oxidized linalool 6.0% in petrolatum (pet.) gave
5% positive patch test reactions in 2500 dermatitis patients.
To investigate whether oxidized linalool 6%, with a stable
concentration of the main haptens, the linalool hydroperoxides (Lin-
OOHs) in pet., could be a useful tool for the detection of contact
allergy in an international setting.
Oxidized linalool 6.0% (Lin-OOHs 1%) pet. was tested in 2900
consecutive dermatitis patients in Denmark, the United Kingdom,
Singapore, Spain, Sweden, and Australia.
Overall, 6.9% (range 3-13%) of the patients showed positive patch test
reactions to oxidized linalool.
Doubtful reactions were found in 9.2% of the patients (range 0-36%).
Few irritant reactions were seen.
In an international setting, oxidized linalool has been shown to be a
Oxidized linalool 6.0% (Lin-OOHs 1%) pet. is a useful, standardized
and stable tool for the detection of contact allergy in dermatitis
Many patients showing positive patch test reactions to oxidized
linalool would not have been informed of their fragrance allergy if
this specific test had not been performed.
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