Discussion:
Oxidative Stress In Asthma
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ironjustice
2011-04-29 16:27:42 UTC
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Oxidative stress and antioxidant status in Saudi asthmatic patients
Original Research Article
In Press, Corrected Proof, Available online 12 February 2011
Nouf O. Al-Afaleg, Abdulrahman Al-Senaidy, Afaf El-Ansary

Abstract
Objectives
Asthma is a chronic inflammatory airway disorder associated with
recruitment of inflammatory cells. This study aims to clarify the role
of oxidative stress and antioxidant status in the deterioration
accompanied asthma.
Design and methods
Vitamin E, Vitamin C, superoxide dismutase (SOD), glutathione
peroxidase (GPx), reduced glutathione (GSH), total antioxidant status
together with the concentrations of lipid peroxides, total nitrates
and oxidative DNA damage (8-oxodeoxyguanine) were determined in plasma
or whole blood of 47 Saudi asthmatic patients and compared to age-
matching control samples.

Results
The present study showed that asthmatic patients have significantly
decreased levels of GSH, α-tocopherol, GPx, total antioxidant status
and higher levels of SOD, lipid peroxides, total nitrate and 8-oxo-dG.
Vitamin C recorded more or less similar levels in both groups.

Conclusion
Alteration of the selected measured parameters confirms that oxidative
stress and defective antioxidant status could represent the primary
causative factor in the pathogenesis of asthma.

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ken
2011-04-29 16:48:16 UTC
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